Postoperative cognitive dysfunction
Conditions
Interventions
Group 1:None
Group 3:Remazolam
Group 4:Serratus anterior plane block combined with remazolam
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 20-65 years, weight 40-66 kg (BMI 18.5-23.9); 2. ASA classification II - III, cardiac function classification I-II.
Exclusion criteria
Exclusion criteria: 1. Minimal Mental State Examination (MMSE) <= 23 points; 2. Secondary surgery; 3. Severe visual or hearing impairment, illiteracy and/or communication difficulties related to pronunciation or dialect; 4. Acute or chronic infectious diseases; 5. Taking anti-inflammatory drugs, immunosuppressants or psychotropic drugs; 6. Lung, brain, liver, kidney and other organ diseases, endocrine system diseases; 7. History of stroke or other neuropsychiatric system diseases, carotid atherosclerosis or stenosis in the previous 6 months; 8. Refusal or accidental discharge.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Delirium assessment;Arterial blood gas analysis;Blood gas analysis of the bulb of right internal jugular vein;Lactic acid;Blood glucose;Arterial jugular bulb oxygen content difference;Cerebral extraction of oxygen;Regional cerebral oxygen saturation;Invasive blood pressure;Mean arterial pressure;Heart rate;Central venous pressure;Pulse oxygen saturation;Urine output;Changes in mean arterial pressure;Heart rate change;Use of vasoactive drugs;Numerical rating scale (NRS);The use of analgesics;Alveolar-arterial oxygen partial pressure difference;Oxygenation index (OI);Respiratory index (RI);Respiratory parameters (tidal volume, respiratory rate, airway peak pressure, mean airway pressure);Extubation time;ICU staying;Secondary intubation rate;Hypotension;Postoperative pulmonary complications;CNS-specific protein (S100ß);Neuron specific enolase (NSE);Glial fibrillary acidic protein (GFAP);Tumor necrosis factor - a (TNF -a);Interleukin-6 (IL-6);C-reactive protein (CRP); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiopulmonary bypass time;Operation time;Anesthesia time;Aortic clamping time;Minimum body temperature;Postoperative complications;The length of hospital stay; | — |
Countries
China
Contacts
Public ContactLu Yizhi
the First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed