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A single-center clinical study of nucleoside (acid) analog antiviral therapy in chronic HBV-infected patients with persistently normal ALT and HBeAg-negative and HBV-DNA positive

A single-center clinical study of nucleoside (acid) analog antiviral therapy in chronic HBV-infected patients with persistently normal ALT and HBeAg-negative and HBV-DNA positive

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100050064
Enrollment
Unknown
Registered
2021-08-16
Start date
2021-08-13
Completion date
Unknown
Last updated
2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic viral hepatitis B

Interventions

case series:none

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. HBsAg positive for at least 6 months before enrollment; 2. HBeAg negative, HBeAb positive, ALT level continued to be normal for at least 1 year (ALT = 2x10^3IU/mL; 3. All patients have not used nucleoside (acid) analogs or interferon antiviral therapy before enrollment, and have not used any hepatoprotective drugs; 4. The diagnosis meets the diagnostic criteria of the ''Guidelines for the Prevention and Treatment of Chronic Hepatitis B'' revised in 2019; 5. Voluntary cooperation to complete the follow-up.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating patients; 2. Under the age of 18; 3. Combined with other hepatitis virus, CMV, HIV and other infections; 4. Combined with other liver diseases such as alcohol, metabolism, drug or autoimmunity; 5. Patients with liver cirrhosis, liver cancer and liver transplantation (Note: Use BMI and ultrasound to exclude fatty liver, ultrasound or CT to exclude liver cirrhosis).

Design outcomes

Primary

MeasureTime frame
curative effect;

Countries

China

Contacts

Public ContactChen Enqiang

West China Hospital of Sichuan University

chenenqiang1983@Hotmail.com+86 18980606517

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026