Atrial fibrillation
Conditions
Interventions
The control group:None
Sponsors
The First Hospital Affiliated of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Aged > 20 years. 2. Non-valvular atrial fibrillation, excluding patients with rheumatic heart disease mitral valve stenosis, biological valve, mechanical valve replacement or valve repair atrial fibrillation. 3. The ECG diagnostic criteria for atrial fibrillation: the PR interval is absolutely different, the P wave disappears, and the atrial excitation cycle is generally 300 beats/min); the differential diagnosis of atrial fibrillation, atrial flutter and atrial tachycardia with irregular cycles is mainly based on the atrial excitation cycle. The guidelines believe that the excitation cycle of atrial flutter and atrial tachycardia is generally >=200ms.
Exclusion criteria
Exclusion criteria: 1. Congenital heart disease, ion channel disease, atrial fibrillation caused by acute coronary syndrome. 2. Cardiac function classification (NYHA classification) is III-IV. 3. Patients with severe systemic diseases (including pulmonary diseases (chronic bronchitis, COPD, pulmonary hypertension), hyperthyroidism, malignant tumors, serious infections). 4. Combined with other atrial arrhythmias, including atrial tachycardia, atrial flutter, etc. 5. Liver and kidney insufficiency: Chronic kidney disease stage 4/5, glomerular filtration rate 3 times normal. 6. Systemic use of oral or intravenous antibiotics within 4 weeks prior to the day of stool sampling. 7. Topical application of a cream/ointment containing antibiotics within 1 week of the stool sampling day. 8. Ingestion of probiotics containing preparations (excluding regular yogurt) within 4 weeks of the stool sampling date. 9. Recent major dietary changes (eg becoming vegetarian). 10. Obesity: Body mass index >=30. 11. Diarrhea and intestinal diseases: inflammatory bowel disease, irritable bowel syndrome, chronic diarrhea, colitis, active infectious gastroenteritis, untreated Helicobacter pylori infection. 12. Gastrointestinal surgery within the past 5 years (excluding cholecystectomy and appendectomy). 13. The patient himself does not agree to be included in the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feces 16SRNA;Acetic acid;Propionic acid;Isobutyric acid;Butyric acid;Isovaleric acid;Pentanoic acid;Caproic acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| III collagen;IV collagen;Hyaluronic acid;Laminin;Homocysteine;Blood sedimentation;Thyroid function;Plasma D dimer;Blood routine;Creatine kinase;Creatine kinase isoenzyme;Myoglobin;Troponin;Blood lipids;Fasting plasma glucose;N-terminal brain natriuretic peptide;Creatinine;Liver function;Creatinine clearance;Echocardiography;Electrocardiogram (ecg); | — |
Countries
China
Contacts
Public ContactZhou Hao
The First Hospital Affiliated of Wenzhou Medical University
Outcome results
None listed