Non-alcoholic fatty liver disease
Conditions
Interventions
Group 1: Ketogenic Diet Program (KDP):Advice on ketogenic diet
Group 2: Lifestyle Modification Program (LMP):Advice on a varied balanced diet with an emphasis on fruit and vegetables, and low-fat, low-glycaemic index and low calorific products in appropriate por
personalized exercise regime
Sponsors
Nil
Eligibility
Sex/Gender
Male
Age
14 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Post-pubertal Chinese adolescents aged 14-18 years with primary obesity attending the Obesity and Lipid Disorder Clinic in PWH (with a visit within the previous year and/or with severe obesity at last visit) and potentially from the endocrine clinics of other Hospital Authority (HA) hospitals. 2. Can read Chinese. 3. Signed informed consent by parents and assent by children. 4. Obese adolescents with suspected NAFLD based on previous ultrasound examination or raised liver enzymes.
Exclusion criteria
Exclusion criteria: 1. Patients with Type II diabetes. 2. Patients with Prader Willi Syndrome. 3. Hepatic viral infection. 4. Daily usage of alcohol, from parental or self-report. 5. BMI below 95th centile of local reference. 6. Using steatogenic and/or anti-diabetic drugs. 7. Concurrent participation in any clinical trial, dietary intervention or weight loss program. 8. Concomitant intake of a weight reducing agent. 9. Any chronic medical illness requiring long term regular medical treatment but to exclude common allergic conditions such as asthma, eczema and allergic rhinitis. 10. Unwillingness to attend regular follow up appointments as part of the intervention program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrahepatic triglyceride content; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical measurements;Anthropometric measurements;Other internal fat parameters like visceral and intra-abdominal fat;Maintenance effect of the intervention;Impact of the interventions on the microbiome composition; | — |
Countries
China
Contacts
Public ContactEdmund Anthony Severn NELSON
The Chinese University of Hong Kong
Outcome results
None listed