cardio-renal-anemia syndrome
Conditions
Interventions
Roxadustat group:Roxadustat capsule
Sponsors
Beijing Hepingli Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Meet the diagnostic criteria of renal anemia and chronic heart failure; 3. NYHA cardiac function grade II - IV, lasting for more than 4 weeks; 4. Non dialysis patients with CKD stage 3a-5; 5. Hb 70 to 100 g / L; 6. Sign informed consent;
Exclusion criteria
Exclusion criteria: 1. Serious cardiovascular and cerebrovascular events within the past 3 months, including myocardial infarction, acute coronary syndrome, stroke, epilepsy or thromboembolism (such as deep vein thrombosis or pulmonary embolism); 2. Chronic inflammatory diseases that affect erythropoiesis, such as systemic lupus erythematosus, rheumatoid arthritis, celiac disease); 3. Patients with anemia caused by causes other than CKD, such as myelodysplastic syndrome, multiple myeloma, hereditary blood diseases, etc.; 4. Women who are pregnant or breastfeeding; 5. Severe hepatic insufficiency; 6. Other serious systemic diseases; 7. Those who are known to be allergic to the test drug and/or its components; 8. Those with mental illness who cannot cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6-minute walk test;echocardiography;inflammatory markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| all cause death, cardiovascular death;cardiovascular events;hospitalization for worsening heart failure;quality of life assessment;progression of cardiac function;anemia related indicators;Safety parameters (ECG, liver function, renal function, blood routine, urine routine); | — |
Countries
China
Contacts
Public ContactWen Yumin
Beijing Hepingli Hospital
Outcome results
None listed