perioperative neurocognitive disorders
Conditions
Sponsors
Xinhua Hospital Affilated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years old; 2. Meet the indications for neurosurgery under general anesthesia; 3. The patient agrees to participate in this trial, and he or his legal guardian signs the informed consent form before the trial.
Exclusion criteria
Exclusion criteria: 1. Liver and kidney insufficiency; 2. History of mental illness, long-term use of sedatives, antidepressants, etc.; 3. History of alcohol and drug abuse; 4. Severe systemic diseases, especially circulatory system diseases: such as myocardial infarction, heart failure, unstable angina, history of sinus bradycardia; 5. Those who cannot tolerate the experiment or cooperate with the inspection due to various reasons, various aphasia, audio-visual dysfunction, cognitive impairment, etc.; 6. Known allergic to Huperzine A; 7. Those who are positive for infectious disease screening; 8. Participated in other clinical trials within 3 months before the start of this study; 9. Systemic dysfunction, CFS-09 grading scale, in line with moderate frailty, severe frailty, very severe frailty and end-stage (such as social and mobility impairment) and/or frailty (2017 ESA guidelines recommend "CFS-09 nine-level classification" Law"); 10. Malnutrition: (1) Diagnostic method 1: BMI10% due to non-artificial factors, or the weight loss is >5% within 3 months; (3) On this basis, one of the following two points can be diagnosed: 1) BMI=70 years old); 2) FFMI<15Kg/m2 (female) or FFMI<17Kg/m2 (male); 11. Subjects deemed unsuitable by the investigator to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Countries
China
Contacts
Public ContactLi Shiting
Xinhua Hospital Affilated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed