carotid plaque with stenosis
Conditions
Interventions
Control group:No
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Those patients with ischemic cerebrovascular disease will be preliminarily screened by carotid ultrasound to pick out the patient with carotid artery plaque and moderate stenosis (50%-69%). The high-resolution MRI will be furtherly carried out to evaluate the plaque volume and the degree of vascular lumen stenosis; 2.Those with age between 50 and 70 years; 3.Those who can persist in taking the experimental drugs for a long time; 4.Those who agree to take part in the clinical research and sign the informed consent document; 5.Those patients that are not suitable for invasive treaments for carotid artery stenosis evaluated by clinicians including carotid endarterectomy and carotid stenting, or in the situation that the patient and family members refuse the corresponding invasive treatment.
Exclusion criteria
Exclusion criteria: 1. Patients who have suffered from hemorrhagic cerebrovascular disease, intracranial aneurysm, severe trauma or major surgery in the past; 2. Patients with severe sequelae from previous stroke (MRS score of 4 and above); 3. Severe stenosis of intracranial arteries (70%~99%); 4. Cardiac ischemic stroke patients; 5. Those with serious heart, liver, kidney and other serious concomitant diseases; 6. Hepatitis B or C, chronic alcoholism; 7. Combined with serious primary diseases such as hematopoietic system, mental patients; 8. Those who affect gastrointestinal absorption (after gastrointestinal ulcer or gastrointestinal surgery) and those with a history of gastrointestinal bleeding; 9. Those who have a history of allergy to the test drug; 10. Those who have had adverse reactions to aspirin and atorvastatin calcium in the past; 11. Those with contraindications to magnetic resonance examination; 12. Those deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plaque composition and stability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plaque volume;Degree of vascular stenosis; | — |
Countries
China
Contacts
Public ContactLin Pengfei
Qilu Hospital of Shandong University
Outcome results
None listed