chronic kidney disease stage 3-4 patients with damp-heat syndrome
Conditions
Interventions
Weak exposure group (oral Qingshen granules 18 months):Qingshen granules
Sponsors
the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years, male or female; 2. Meet the diagnostic criteria of CKD stage 3a-4, as well as the syndrome differentiation criteria of TCM damp-heat syndrome; 3. Blood pressure =80g/L, infection under control, and stable condition for more than 2 weeks at the time of enrollment; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating patients; 2. Unable to cooperate, such as mental patients; 3. Combined with serious primary diseases such as active malignant tumor, decompensated liver cirrhosis or hematopoietic system; 4. Patients with infectious diseases; 5. There is acute urinary tract obstructive disease, requiring surgical treatment; 6. Severe arrhythmia, severe heart failure, NYHA class III and above (evidence of New York Heart Association class III and IV), or myocardial infarction or cerebrovascular events within 3 months before enrollment; 7. Are using corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressants; 8. Those undergoing emergency hemodialysis; 9. Those who have undergone kidney transplantation and total or partial parathyroidectomy; 10. Those who are known to be allergic to or intolerable to a certain drug in this study; patients who are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood creatinine doubled;First dialysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular events;Detection of vascular calcification;Mineral and bone metabolism indexes; | — |
Countries
China
Contacts
Public ContactWang Yiping
the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Outcome results
None listed