Intervertebrl disc degeneration
Conditions
Interventions
Experimental group:discectomy combined with transplantation of autologous discogenic cells
Control group:Discectomy alone
Sponsors
the Sixth Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
21 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 to 60 years; 2. Single-level lumbar disc herniation confirmed on MRI that was consistent with history and physical examination; 3. Clinical diagnosis of low back pain and/or sciatica; 4. Failed conservative treatment (i.e. physical therapy, medications, epidural injection,) for a minimum of 6 months.
Exclusion criteria
Exclusion criteria: 1. Previous surgery at the lumbar levels; 2. Disc re-herniation treated with nucleotomy / sequestrectomy of the relevant disc; 3. Degenerative changes in the lumbar as determined by Modic Changes 2 or 3/Pfirrmann 4 or 5; 4. Segment instability (spondylolisthesis >5mm or translation >3mm); 5. Body Mass Index> 30 kg/m2; 6. Severe cardiac disease, pulmonary disease, active neoplasm, anemia or any other surgical contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Visual Analog Scale;the Oswestry Disability Index (ODI);The Short form health survey-36 (SF-36);Japanese Orthopaedic Association (JOA) scoring system;disc height index;the ratio value of the grayscale; | — |
Secondary
| Measure | Time frame |
|---|---|
| the apparent diffusion coefficient (ADC);Numberof CEP defects; | — |
Countries
China
Contacts
Public ContactDike Ruan
the Sixth Medical Center of PLA General Hospital
Outcome results
None listed