Sarcopenia
Conditions
Interventions
Experimental Group:whey protein-based nutritional formula supplementation
Control group:iso-caloric control formula supplementation
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 70 years old; 2. BMI<30kg/m2 3. Diagnosed with sarcopenia; 4. Willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are participating in clinical trials of other drugs; 2. Patients with severe cardiovascular disease (NYHA class III-IV), severe aortic stenosis, previous history of cardiac arrest, installation of pacemaker or internal automatic defibrillator, and repeated angina pectoris in the past six months; 3. Patients with severe cerebrovascular disease (hemiplegia and poor mobility after previous stroke) and Parkinson's disease; 4. Patients with severe cognitive impairment (MMSE 150umol/L, or eGFR<=30ml/min), hepatic insufficiency (Child-Pugh BC grade), calcium metabolism disorders (including but not limited to abnormal parathyroid gland function) , secondary osteoporosis), hyperthyroidism, immunodeficiency diseases, other serious diseases that may threaten life, such as cancer (cancer-related treatment within the past 3 years); 6. Suffering from muscle disease, taking drugs that affect muscle function; suffering from diseases affecting limb movement, such as patients with severe joint disease (including but not limited to osteoarthritis or rheumatoid arthritis, patients undergoing joint replacement surgery), the installation of prosthetic limbs patient; 7. Patients who have undergone surgery within the past 1 month; 8. Actively lose weight or gain weight in the past six months, and take drugs that may cause weight changes (such as hormones, nutritional supplements, protein powder, amino acid health products); 9. Survival time due to a major disease, expected survival time < 6 months; 10. Patients who are allergic to ingredients in nutritional intervention preparations.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Skeletal muscle mass;Grip strength;Short Physical Performance Battery; | — |
Countries
China
Contacts
Public ContactLuo Man
Zhongshan Hospital, Fudan University
Outcome results
None listed