The effect of sub-anaesthetic dose of esketamine on postoperative recovery quality and perioperative pain and depression of gynecological patients undergoing laparoscopic hysterectomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100049857

Enrollment

Unknown

Registered

2021-08-10

Start date

2021-08-10

Completion date

Unknown

Last updated

2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

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Interventions

Group 1:0.5 mg/kg esketamine intravenously after induction of anesthesia

Group 2:propofol

Eligibility

Sex/Gender

Female

Age

25 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Aged 25 to 55 years; 2. ASA classification I-II; 3. BMI 18-27kg/m2; 4. Agree to participate in the experiment and sign the written informed consent.

Exclusion criteria

Exclusion criteria: 1. Allergy to anesthetics; 2. Alcoholism; preoperative neurological disease, long-term use of sleeping pills and sedatives; 3. Anemia Hb less than 90g/L; 4. Diabetes; 5. Moderate to severe hypertension; 6. Severe cardiopulmonary dysfunction; 7. Severe liver and kidney dysfunction; 8. Thyroid dysfunction; 9. Menopausal women.

Design outcomes

Primary

Measure	Time frame
Postoperative recovery quality;	—

Secondary

Measure	Time frame
Hamilton Depression Scale;Numerical Rating Scale;Number of remedial analgesia in the ward within three days after surgery;	—

Countries

China

Contacts

Public ContactZhang Jing

Xuzhou Medical University

981726732@qq.com+86 19552151026

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026