Cognitive dysfunction after stroke
Conditions
Interventions
High frequency rTMS group:No
The low frequency rTMS group:No
Cognitive function training group:No
Sponsors
Shanghai Tongren Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The first onset, the course of disease >= 3 months; 2. The vital signs are stable, and the symptoms do not progress; 3. Consciousness, no serious aphasia and obvious cognitive dysfunction before the onset (11 points < MoCA score < 26 points, can cooperate with the completion of treatment and evaluation; 4. No stroke lesions in key parts (hippocampus, thalamus, large cortical lesions) 5. Age < 70 years old, all subjects are right-handed; 6. All patients participated voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Multiple episodes; 2. There is a history of transcranial surgery; 3. Patients with metal foreign bodies or implanted electronic devices in the body, which are contraindications to rTMS treatment; 4. History of traumatic brain injury, cerebral hemorrhage, epilepsy, cognitive impairment and mental illness in the past; 5. Severe white matter degeneration Fazekas scale score> 1; 6. Cognitive deficits caused by other reasons (such as drug abuse, heavy drinking, etc.); 7. Combined with severe liver, kidney, heart disease or other serious physical diseases; 8. Patients with severe hearing, vision, language impairment and other reasons who cannot cooperate with clinical examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Stroop color word interference test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wired Quiz;Event-related potential P300;Resting state electroencephalography;Resting state functional magnetic resonance; | — |
Countries
China
Contacts
Public ContactZhang Jingjing
Shanghai Tongren Hospital
Outcome results
None listed