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Effects of percutaneous aural vagus nerve stimulation on immune function in patients with sepsis: a randomized controlled study

Effects of percutaneous aural vagus nerve stimulation on immune function in patients with sepsis: a randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049823
Enrollment
Unknown
Registered
2021-08-10
Start date
2021-10-01
Completion date
Unknown
Last updated
2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

Experimental group:Ovagus nerve stimulation
Control Group:Left shoulder electrode stimulation

Sponsors

The Second Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
14 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.SOFA score >=2 points; 2. Aged > 14 years old; 3. Both men and women; 4. Signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Participated in other clinical trials within 3 months prior to inclusion in this study; 2. Autoimmune diseases; 3. Diseases of the blood system; 4. A history of splenectomy; 5. Pregnant or lactating women; 6. A history of bradycardia; 7. Allergic to electrodes.

Design outcomes

Primary

MeasureTime frame
Cytokine levels;Lymphocyte count and 100 %;—

Secondary

MeasureTime frame
Duration in the Intensive Care Unit;28-day mortality rate;Secondary infection rate in Intensive Care Unit;Incidence of functional failure;hospital stays;all-in cost;hepatic renal insufficiency;Heart rate changes before and after stimulation;—

Countries

China

Contacts

Public ContactLi Xueqing

The Second Hospital of Hebei Medical University

Lixueqingsophia@sina.com+86 18233120987

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026