acute pancreatitis
Conditions
Interventions
Rifaximin group:Oral Rifaximin
control group:None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years; 2. Within 72 hours of onset; 3. Patients with predicted SAP (Acute Physiology and Chronic Health Evaluation II score, APACHE II score >= 8) or SAP patients who meet the diagnostic criteria for SAP in the 2012 Atlanta Classification and Diagnostic Criteria for AP (patients with AP with persistent (>48 h) organ failure, including respiratory failure, circulatory failure, or renal failure, with organ failure defined as a modified Marshall score >= 2.); 4. No antibiotics were applied within 14 days prior to admission; 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe multi-organ failure judged by physicians to be on the verge of death; 2. Pregnant and lactating women; 3. Pancreatitis after endoscopic retrograde cholangiopancreatography; 4. Patients with concomitant gastrointestinal bleeding; 5. Patients with intestinal obstruction and severe intestinal lesions; 6. Those who are allergic to other rifamycin analogs of rifaximin; 7. Chronic pancreatitis, suspected malignancy of the pancreas or biliary tract.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infectious complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of infection at various sites;Time of occurrence of infection;Microbial culture results ;Antibiotic resistance;body temperature;Procalcitonin, PCT;CRP;NE%;IL-6;TNF-a;Intravenous antibiotic use;Mortality;Incidence of organ failure;Incidence of minimally invasive procedures and surgical procedures;Length of hospitalization;Intensive care time;Hospitalization Costs; | — |
Countries
china
Contacts
Public ContactLu Huanong
The First Affiliated Hospital of Nanchang University
Outcome results
None listed