The effect of liquid pre-expansion and vasoactive drugs on oxygen consumption in patients under general anesthesia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100049779

Enrollment

Unknown

Registered

2021-08-09

Start date

2021-08-16

Completion date

Unknown

Last updated

2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oxygen consumption

Interventions

Group I:fluid pre-expansion

Group II:fluid infusion after anesthetic induction

Group III:fluid infusion according to clinical protocol

Gourp IV:bolus of norepinephrine

Group V:infusion of norepinephrine

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. ASA I - II; 2. Aged > 18 years old male and female; 3. BMI<35kg/m2; 4. Central venous catheterization was performed before operation; 5. Elective surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Cardiac insufficiency, severe arrhythmia, aortic regurgitation, etc.; 2. Abnormal coagulation function; 3. Abnormal liver and kidney function before operation; 4. Obstructive pulmonary disease (airway pressure>25mmHg); 5. Emergency surgery; 6. Preoperative infection exists.

Design outcomes

Primary

Measure	Time frame
oxygen consumption;	—

Secondary

Measure	Time frame
Blood gas anylysis;Blood pressure;Heart rates;oxygen supply;cardiac output;	—

Countries

China

Contacts

Public ContactQiu Huanrong

Beijing Friendship Hospital, Capital Medical University

18500591351@163.com+86 15210682411

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026