abdominal surgery
Conditions
Interventions
k receptor analgesic drug group:Use k receptor analgesic drug for analgesia
µ receptor analgesic drug group:Use µ receptor analgesic drug for analgesia
Sponsors
the Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with abdominal surgery who need postoperative analgesia and ICU monitoring; 2. Aged 18 to 80 years; 3. The estimated treatment time in the ICU is greater than 7 days; 4. Voluntarily sign the informed consent and participate in the research.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to opioids; 2. Patients with gastrointestinal ischemia and other diseases; 3. Mental patients; 4. Long-term use of opioids for more than 2 weeks (oral or intravenous, pain reliever), drug addiction; 5. Liver and kidney insufficiency (liver enzymes are more than 3 times the normal value or child score is more than grade B; creatinine clearance rate <50ml/min); 6. Patients with bradycardia (heart rate <= 50 beats/min), third-degree atrioventricular block, systolic blood pressure <= 90 mmHg; 7. Pregnant or lactating women; 8. Patients with persistent epilepsy; 9. Patients with severe gastrointestinal dysfunction; 10. Patients who are expected to die within 48 hours; 11. Those who participated in other clinical trials within 30 days before enrollment; 12. Those who are deemed inappropriate by the investigator to participate in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal function;analgesic effect;Mechanical ventilation time;Duration of ICU stay; | — |
Countries
China
Contacts
Public ContactLiu Xuefang
the Second Hospital of Hebei Medical University
Outcome results
None listed