Carotid stenosis
Conditions
Interventions
Experimental group:Maintain the partial pressure of end-tidal carbon dioxide at 45-50mmHg after carotid artery occlusion and 30-35mmHg after opening
Control group:No
Sponsors
Xuanwu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing carotid endarterectomy under elective general anesthesia admitted to the Department of Neurosurgery, Xuanwu Hospital of CCMU; New York Heart Association functional classI-III; American Society of Anesthesiologists (ASA) physical status I-?; BMI18.5-29.9kg/?; Volunteer for the study and to sign an informed consent.
Exclusion criteria
Exclusion criteria: Abnormal myocardial enzyme indexes before operation; Transesophageal echocardiography is not clear; Contraindication of transesophageal ultrasound probe placement, such as congenital or acquired diseases of the upper digestive tract, pharyngeal abscesses and occupying lesions of the pharynx, severe and inadequately fixed cervical trauma, etc; Patients in other studies; Patients who also undergo other surgeries; Severe liver and kidney disfunction; Chronic obstructive pulmonary disease; Transcranial Doppler ultrasound cannot be detected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| E/e' ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| global longitudinal strain;invasive arterial blood pressure;heart rate;cardiac output;cardiac cycle efficiency;systemic vascular resistance;regional cerebral oxygen saturation;myoglobin;troponin;creatine kinase-MB;N-terminal natriuretic peptide precursor;intraoperative dose of vasoactive drugs;postoperative complication rate; | — |
Countries
China
Contacts
Public ContactZhao Lei
Xuanwu Hospital of Capital Medical University
Outcome results
None listed