Adverse reactions related to narcotic drugs
Conditions
Interventions
Control group:None
Group V :Butorphanol 1 mg intravenously 2 minutes before induction
Group NL :Butorphanol 1mg intranasal 15 minutes before induction
Group NH :Butorphanol 2mg intranasal 15 minutes before induction
Sponsors
Hu'nan Provincial People's Hospital (The First Affiliate Hospital of Hu'nan Normal University )
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. Patients receiving elective general anesthesia; 3. ASA score is I-III; 4. 18.5 kg/m^2<BMI<30kg/m^2; 5. Clearly understand and voluntarily participate in the research, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Opioid-tolerant patients; 2. Patients who are dependent on narcotine; 3. Pregnant and lactating patients; 4. Those who are mentally ill or unable to cooperate for other reasons; 5. Patients with central nervous system disease before surgery; 6. History of chronic pain (pain symptoms for more than 3 months); 7. Patients taking sedatives, antidepressants or drugs that excite the central nervous system before surgery; 8. Patients with a history of allergies; 9. Patients with bronchial asthma or chronic obstructive pulmonary disease before surgery; 10. Patients who have taken steroids and bronchodilators in the past two weeks; 11. Those with upper respiratory tract infection within the past two weeks; 12. History of PONV or motion sickness; 13. Patients with myocardial infarction, ventricular dysfunction, and coronary insufficiency; 14. Participate in other drug clinical investigators within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of coughing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of occurrence;Vital signs;Intraoperative blood loss;Intraoperative urine output;Intraoperative fluid input;Postoperative extubation time;Ramsay sedation score;Rest-lessness score;Postoperative nausea and vomiting score; | — |
Countries
China
Contacts
Public ContactPan Bingbing
Hu'nan Provincial People's Hospital (The First Affiliate Hospital of Hu'nan Normal University )
Outcome results
None listed