Depression
Conditions
Interventions
Healthy control group:None
Depression group:Medications
Sponsors
Daizhuang Hospital of Shandong Province
Eligibility
Sex/Gender
All
Age
15 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Outpatient or inpatient patients aged 15 to 55 years (including 15 and 55), regardless of gender; 2. Meet the diagnostic and statistical manual of mental disorders 5th edition (DSM-5) diagnostic criteria for depressive disorders (diagnosis confirmed by the MINI stereotyped interview), either the first episode or the relapse; 3. HAMD-17 total score >=14 at screening; 4. Primary school education level or above, able to understand the content of the scale; 5. The patient himself signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Currently or in the past with DSM-5 other important diagnoses other than depressive disorders, including schizophrenia, schizoaffective disorder, bipolar disorder, neurodevelopmental disorder and neurocognitive disorder; 2. Patients with a history of alcohol and drug dependence; 3. The course of the depressive episode >= 2 years; 4. Patients with refractory depression (with 2 antidepressants with different mechanisms of action for this episode, the symptoms are relieved by a sufficient amount and a full course of treatment <50%); 5. Pregnant or lactating patients; 6. At present, there are serious physical diseases that the researchers think are not suitable to be included in this study; 7. Any other situation that the investigator considers unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of score of HAMD-17 compared with baseline assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of score of QIDS-SR16 compared with baseline assessment;Functional magnetic resonance imaging;Blood and fecal metabolites; | — |
Countries
China
Contacts
Public ContactCui Jian
Daizhuang Hospital of Shandong Province
Outcome results
None listed