Breast cancer
Conditions
Interventions
group A:General anesthesia (intravenous induction + inhalation maintenance)
group B :General anesthesia + thoracic paravertebral nerve block
Sponsors
Cancer Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients who voluntarily participated in the study and signed a written informed consent; 2. Females aged 18-60 years when signing the informed consent form; 3. Histologically or cytologically confirmed breast adenocarcinoma; 4. It is planned to undergo unilateral modified radical surgery for breast cancer under elective general anesthesia; 5. American society of anesthesiologists (ASA) grade I or II; 6. Asian race.
Exclusion criteria
Exclusion criteria: 1. Patients with inflammatory diseases; 2. Patients who have received surgical treatment within the past 30 days; 3. Pregnant patients; 4. Patients with liver and kidney diseases; 5. Long-term drinking, long-term use of psychotropic drugs such as sedatives or antidepressants; 6. There are contraindications for paravertebral nerve block, including severe abnormal coagulation function, infection at the puncture site, trauma or history of spinal surgery; 7. Unable to cooperate with the research for any reason, such as the following situations: difficulty in language comprehension, mental illness, inability to visit the hospital for follow-up, etc.; 8. Taking other experimental drugs or participating in other clinical trials within 3 months before being enrolled in the study; 9. Preoperative radiotherapy or chemotherapy; 10. Other situations that the investigator thinks should not be included in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VEGF-C;TGF-ß;Myeloid-derived suppressor cells;Neutrophil-lymphocyte ratio (NLR);Immune related cytokines;Pain score VAS;Recurrence-free survival ;Overall survival,OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative anesthetic maintenance dose;Hemodynamic indexes;Recovery room residence time;QoR-40 score;Complications;Anesthesia satisfaction; | — |
Countries
China
Contacts
Public ContactYan Tao
Cancer Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed