post-stroke cognition impairment
Conditions
Interventions
rTMS Group 1:TPC
5 Hz
100%RMT
1200 pulses (10s × 24 trains, 25s interval)
rTMS Group 2:IFG
20 Hz
90%RMT
1200 pulses (2s × 30 trains, 25s interval)
rTMS Group 3:IFG
600 pulses (2s × 30 trains, 25s interval)
rTMS Group 4:TPC
2000 pulses (10s × 20 trains, 30s interval)
rTMS Group 5:DLPFC
600 pulses (4s × 30 trains, 25s interval)
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 and 75 years; 2. Right-handed; 3. Patients who meet the diagnostic criteria for vascular cognitive impairment in the ''Consensus Research Guidelines for the Classification of Vascular Cognitive Impairment in Cognitive Function'' and ''Chinese Guidelines for Vascular Cognitive Impairment 2019'' are mainly summarized as follows: (1) At least one cognitive impairment (MoCA<=24) confirmed by clinical and neuropsychological assessment, and the presence or absence of activities of daily living impairments (IADLs); (2) Imaging evidence of stroke confirmed by magnetic resonance imaging (MRI); (3) Cognitive impairment should be independent of motor/sensory sequelae of vascular events, and there should be a clear temporal relationship between vascular events and the onset of cognitive impairment (within 6 months and for at least 3 months); 4. No severe aphasia, able to complete the cognitive test; 5. Normal cognitive function before stroke; 6. Voluntarily participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Drug/alcohol abuse/dependence within the last 3 months after initial detection of injury. 2. Contraindications to rTMS treatment, such as epilepsy patients, pregnant or breastfeeding women, or the use of metal or electrical implantable devices (eg deep brain stimulators, ventriculoperitoneal shunts, aneurysm clips, pacemakers, cochlea, surgical staples on the scalp). 3. MRI contraindications (such as metal implants or claustrophobia). 4. Participate in pharmacological or non-pharmacological treatment research at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale Beijing Edition;Connection Test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improved Chinese version of Barthel index;Lawton Instrumental Activities of Daily Living;Stroke Specific Quality of Life Assessment Scale;LFO Amplitude;Brain Functional Connectivity; | — |
Countries
China
Contacts
Public ContactLi Lingxin
West China Hospital, Sichuan University
Outcome results
None listed