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Comparison of the clinical efficacy of dydrogesterone and medroxyprogesterone acetate for progestin primed ovarian stimulation in patients with poor ovarian response: a multicenter randomized controlled study

Comparison of the clinical efficacy of dydrogesterone and medroxyprogesterone acetate for progestin primed ovarian stimulation in patients with poor ovarian response: a multicenter randomized controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049623
Enrollment
Unknown
Registered
2021-08-07
Start date
2021-09-01
Completion date
Unknown
Last updated
2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

poor ovarian response

Interventions

Sponsors

Lanzhou University Second Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Voluntarily participate, understand and sign the informed consent; 2. In line with IVF indications; 3. Aged between 20-45 years; 4. Patients diagnosed with POR according to the POR criteria established by The European Society for Human Reproduction and Embryology (ESHRE) in 2011.

Exclusion criteria

Exclusion criteria: 1. Contraindications to IVF treatment (previous history of arterial thromboembolic disease (such as stroke, cardiac infarction). Current or previous history of lower extremity deep vein thrombosis or pulmonary embolism. Current or past history of thromboembolism, active thrombophlebitis, or cerebrovascular disease. Severe liver, kidney, heart, lung dysfunction; history of malignant tumors, serious genetic diseases, etc.); 2. Patients diagnosed with PCOS according to Rotterdam criteria ; 3. Patients with normal ovarian function; 4. Chromosomal abnormalities in one parent; 5. Those who are allergic to dydrogesterone; 6. Patients who are allergic to medroxyprogesterone; 7. Participate in other drug clinical investigators within 1 month.

Design outcomes

Primary

MeasureTime frame
The number of oocytes retrieved;

Secondary

MeasureTime frame
The incidence of premature luteinizing hormone peaks;Human menopausal gonadotropin dosage;Human menopausal gonadotropin use time;The diameter of the follicle before ovulation;MII oocytes rate;Fertility rate;Top-qualified embryo rate;Viable embryo rate;Embryo implantation rate;Clinical pregnancy rate;Early abortion rate;Hormonal level;

Countries

China

Contacts

Public ContactWang Fang

Lanzhou University Second Hospital

ery_fwang@lzu.edu.cn+86 13919302888

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026