neonatal respiratory distress syndrome (NRDS)
Conditions
Interventions
Group 1:nasal intermittent positive pressure ventilation
Group 2:nasal continuous positive pressure ventilation
Sponsors
Shanghai First Maternity and Infant Hospital, Tongji University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The gestational age at birth is less than 32 weeks, and the daily age is less than or equal to 6 hours (the assessment of gestational age is based on the first trimester ultrasound and the last menstrual period of the pregnant woman); 2. Progressive respiratory distress-related manifestations within 6 hours, with at least 2 of the following manifestations: shortness of breath (breath rate > 60 breaths/min), alar flap, moaning, three concave sign (suprasternal fossa, intercostal space, subxiphoid) positive, cyanosis and consistent with NRDS findings on chest X-ray or lung ultrasonography within 6 hours after birth; 3. Active spontaneous breathing; 4. Description of special circumstances: (1) Those who needed tracheal intubation resuscitation in the delivery room but were active spontaneously breathing after arriving in the ward were included in the study; (2) Invasive ventilation was given to patients with weak spontaneous breathing after birth, but active spontaneous breathing within 6 hours after birth. Clinicians considered that they could meet the indications of non-invasive ventilation and were included in the study.
Exclusion criteria
Exclusion criteria: 1. Death within 6 hours of admission or transfer due to insufficient beds; 2. Combined with cyanotic heart disease, diaphragmatic hernia, major congenital malformation or chromosomal abnormality, neuromuscular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Intrusive mechanical ventilation;The incidence of bronchopulmonary dysplasia; | — |
Countries
China
Contacts
Public ContactWang Tingting
Shanghai First Maternity and Infant Hospital, Tongji University
Outcome results
None listed