Hyperoxemia
Conditions
Interventions
FiO2 group:FiO2 was 100% during pre-oxygenation and 60% perioperatively
iFiO2 group:FiO2 at 60% during pre-oxygenation, with SpO2-guided iFiO2 titration to control arterial oxygenation in perioperative patients
Sponsors
the Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing gastrointestinal surgery under elective general anesthesia, aged >=40 years, and ASA grade I-III; 2. Expected mechanical ventilation time > 3 hours, pulse perfusion index (PI > 1.4); 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients or family members who are unable or unwilling to cooperate; 2. Patients who live in plateau areas; 3. Preoperative hemoglobin <110g/L for women and <120g/L for men; 4. Preoperative SpO2<=94%; 5. Patients with severe cardiopulmonary disease; lung ultrasound imaging is not clear.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of atelectasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| iFiO2 required to maintain physiological oxygenation during perioperative period;Oxygenation index;Intrapulmonary shunt;Alveolar arterial oxygen differential pressure;Blood lactate value;Serum MDA, SOD;SpO2 < 90% incidence;Vital capacity (VC), minute ventilation (MV);Incidence of postoperative nausea and vomiting;Incidence of surgical incision infection;Length of stay;Residence time in recovery room after anesthesia;Intubation time and SpO2 immediately after intubation;Time to extubation indication after drug withdrawal;Dynamic lung compliance; | — |
Countries
China
Contacts
Public ContactZhang Bing
the Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed