carotid plaque with stenosis
Conditions
Interventions
control group:Placebo
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with ischemic cerebrovascular disease with carotid plaque and moderate stenosis (50%-69%) were initially screened by carotid ultrasound or cervical vascular MRA, and further accurate assessment of carotid artery lumen stenosis by high-resolution MRI was moderate stenosis (50%-69%); 2. Aged 50-70 years; 3. Those who can insist on taking this experimental drug for a long time; 4. Those who agree to participate in this clinical study and sign the informed consent; 5. Invasive treatments for carotid artery stenosis that are not suitable for carotid artery stenosis after evaluation by clinicians include carotid endarterectomy and carotid stenting, or the patients and their families refuse to undergo corresponding invasive treatments.
Exclusion criteria
Exclusion criteria: 1. Patients who have suffered from hemorrhagic cerebrovascular disease ,intracranial aneurysm, severe trauma or after major surgery; 2. Patients with severe sequelae from previous strokes (MRS score 4 points and above); 3. Patients with severe intracranial artery stenosis (70%~99%); 4. Patients with cardiogenic ischemic stroke; 5. Patients with serious heart, liver, kidney diseases or other serious concomitant diseases; 6. Patients with chronic hepatitis B, chronic hepatitis C or chronic alcoholism; 7. Patients with severe primary diseases such as hematopoietic system disease or mental illness; 8. Those with poor gastrointestinal absorption after gastrointestinal ulcer or gastrointestinal surgery; 9. Patients with a history of allergies to test drugs; 10.Patients who have had previous adverse reactions to aspirin and rosuvastatin; 11.Patients who are contraindicated in MRI; 12.Patients who are not believed to be suitable for enrollment by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid plaque volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of vascular stenosis; | — |
Countries
China
Contacts
Public ContactLin Pengfei
Qilu Hospital of Shandong University
Outcome results
None listed