None listed
Conditions
Interventions
Group 1:Etomidate and sevoflurane
Group 2:Propofol and sevoflurane
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. Type of surgery: laparoscopic gynecological surgery, laparoscopic gastrointestinal surgery, thoracoscopic radical resection of lung cancer; 3. 1 h <= operation time <= 3 h; 4. ASA classification I-III; 5. BMI is 18.5-29.9 kg/m^2 [BMI=weight (Kg)/height (m)^2] (2013 American ''Adult Overweight and Obesity Management Guidelines''); 6. In line with ethics, the patients were tested voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Cerebrovascular accident occurred within 3 months, such as stroke, transient ischemic attack (TIA), etc.; 2. Patients with severe abnormal liver and kidney function (severe liver function abnormality: one of ALT, AST, ALP, total bilirubin, etc. > 2 times the upper limit of the normal value. Severe renal dysfunction: creatinine > 2 times the upper limit of the normal value); 3. Patients with diabetic complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macrovascular disease, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.); 4. Those who have experienced unstable angina pectoris or myocardial infarction within 3 months; 5. Preoperative visit blood pressure >= 160/100 mmHg (2020 ISH Hypertension Guidelines >= grade 2 hypertension); 6. Confirmed/suspected of abuse or long-term use of narcotic sedative analgesics; 7. Those who have taken hormones or other immunosuppressive agents for >10 days within half a year, or have a history of adrenal cortex suppression or immune system diseases; 8. Those with hypothyroidism; 9. Those with a history of asthma; 10. Reoperation within 3 months; 11. Those who have contraindications or allergies to experimental drugs and other anesthetic drugs; 12. Patients enrolled in other studies within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of intraoperative hypertension and hypotension;Ricker sedation-agitation score after surgery; | — |
Countries
China
Contacts
Public ContactZhang Jiaqiang
He'nan Provincial People's Hospital
Outcome results
None listed