Ulcerative colitis with depression
Conditions
Interventions
experimental group:FMT capsules intervention
Sponsors
Army Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. The course of disease is more than 6 months, and the diagnosis is ulcerative colitis with depression [Diagnostic criteria reference: (2020) "JSGE Evidence-based Clinical Practice Guidelines: Inflammatory Bowel Disease" and "Chinese Classification and Diagnostic Criteria for Mental Disorders" (CCMD) -3), and meet the modified Mayo score = 5 points]; 2. Men and women are not limited, the age is between 18-65 years old; 3. BMI between 18-30kg/m2; 4. Have basic reading comprehension skills; 5. No other serious diseases of the heart, brain, lung, liver, kidney, etc.; 6. Have not traveled abroad in the past 1 month, and have no history of alcoholism, drug addiction, or travel; 7. No use of antibiotics and probiotics within 1 month; 8. Agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Authors with bipolar affective disorder, persistent mood disorder, and mania; 2. Gastrointestinal infection, irritable bowel syndrome, bowel cancer and other malignant tumors and other gastrointestinal diseases; 3. A history of gastrointestinal surgery; 4. Pregnancy and lactation patients; 5. Complicated with severe chronic diseases (hereditary, metabolic, endocrine diseases) such as obesity, hypertension, diabetes, heart disease, and stroke; 6. Infectious diseases: hepatitis B or C, HIV, syphilis (positive plasma rapid recovery), Epstein-Barr virus and cytomegalovirus infection (IgM positive); 7. Abnormal liver function: AST or ALT higher than 2 times the upper limit of normal; renal insufficiency: serum Cr higher than 1.5 times the upper limit of normal or eGFR 4.0 mmol/L, TG >2.0 mmol/L, LDL-c>2.5 mmol/L, HDL-c8 mg/L; 8. Anticoagulation therapy; 9. Patients who are participating in other clinical trials at the time of enrollment; 10. Those who do not agree to be enrolled or have various factors that affect compliance and are not suitable for participating in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PHQ9 Scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| gut microbiota;Conlonscopy Mayo index;Anxiety and Depression Scale Assessment; | — |
Countries
China
Contacts
Public ContactWei Yanling
Army Medical Center
Outcome results
None listed