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Effect of Partially hydrolyzed guar gum on postoperative intestinal flora and immune status in patients with gastrointestinal tumors: a randomized controlled study

Effect of Partially hydrolyzed guar gum on postoperative intestinal flora and immune status in patients with gastrointestinal tumors: a randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049489
Enrollment
Unknown
Registered
2021-08-02
Start date
2021-10-03
Completion date
Unknown
Last updated
2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastrointestinal tumour

Interventions

Experimental group:Provide nutritional support to Jiashan Jialichang
Control Group:Provide nutritional support

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients who need to receive enteral nutrition support and undergo gastrointestinal tumor surgery; 2. Aged 18 to 75 years; 3. BMI 18.5-28.0 kg/m2 (inclusive) on admission; 4. APACHE-II score = 7 days; 6. Sign the informed consent form voluntarily, and complete the questionnaire survey and follow-up as required; when it is impossible to sign the informed consent form and complete the questionnaire survey and follow-up visit, the legal representative or guardian can act on his behalf.

Exclusion criteria

Exclusion criteria: 1. BMI 28.0 kg/m2; 2. Unable to establish enteral nutrition pathway; 3. Presence of hemodynamic instability, gastrointestinal bleeding, postoperative acute pancreatitis, inflammatory bowel disease (Crohn's disease or ulcerative colitis), intestinal ischemia, persistent intestinal obstruction, intestinal paralysis, high flow Patients with enteral nutrition contraindications such as intestinal atrophy and inability to establish remote access; 4. Patients with infectious diarrhea; 5. Bone marrow or organ transplant patients; 6. Other patients with leukopenia, neutropenia, malignant blood diseases, HIV and other clinically deemed unsuitable to participate in this study; 7. Patients with renal insufficiency (eGFR < 60mL/min), or patients requiring dialysis treatment; 8. Thyroid dysfunction; 9. The patient himself, legal representative or guardian refuses to participate in the researcher; 10. Pregnant or lactating female patients; 11. Those who are known to be allergic to any of the ingredients in the research or control products, or those who need to limit dietary fiber intake in the judgment of the investigator; 12. Galactosemia; 13. Expected survival <= 10 days.

Design outcomes

Secondary

MeasureTime frame
Peripheral blood immune indicators;

Countries

China

Contacts

Public ContactWu Xiaoting

West China Hospital, Sichuan University

wxt1@medmail.com.cn+86 18980601493

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026