postoperative nausea and vomiting (PONV)
Conditions
Interventions
control group:None
Experimental group1:After ONSD was increased, 20% mannitol 0.25g/kg was quickly dropped intravenously.
Experimental group2:Before ONSD was increased, 20% mannitol 0.25g/kg was quickly dropped intravenously.
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
Female
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients who planned to undergo total hysterectomy under laparoscopic combined general anesthesia; 2. ASA I or II; 3. Aged 35 to 70 years; 4. BMI 18.5-27.9 kg/m2; 5. The operation is expected to take more than 90 minutes.
Exclusion criteria
Exclusion criteria: 1. Patients with a previous history of eye disease or eye surgery; 2. Patients with a history of neurological disease or transient ischemic attack; 3. Patients with poor ultrasound image quality; 4. Patients who need to be converted to open surgery intraoperatively; 5. Patients with hemodynamic instability during perioperative period; 6. Patients with intraoperative peak airway pressure greater than 35mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue score of Postoperative nausea and vomiting;Semantic difference Scale of Postoperative nausea and vomiting;The incidence of Postoperative nausea and vomiting;Diameter of optic nerve sheath; | — |
Secondary
| Measure | Time frame |
|---|---|
| Apfels’s score;Visual analogue score of postoperative headache;Systolic/diastolic/mean arterial pressure;Heart rate;Oxygen saturation of finger vein;The airway peak pressure;End-tidal carbon dioxide partial pressure;Bispectral index;Duration of pneumoperitoneum/head down tilt;Time spent in the recovery room;Intraoperatve blood soss;Urine amount;Intraoperative fluid/blood transfusion volume;Postoperative antiemetic drugs;Opioid analgesics after surgery;Pneumoperitoneum pressure;Head down tilt angle; | — |
Countries
China
Contacts
Public ContactZhang Bing
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed