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Fecal bacteria transplantation in treatment of patients with advanced cancer

Fecal bacteria transplantation in treatment of patients with advanced cancer

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049431
Enrollment
Unknown
Registered
2021-08-02
Start date
2021-08-02
Completion date
Unknown
Last updated
2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver, colon, gastric, pancreatic, and lung cancer

Interventions

Sponsors

Tongji Chibi Hospital of Huazhong University of Science and Technology (Chibi Pufang Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients who are clinically diagnosed as late, middle or late stage by histology and cytology; 2. Life expectancy of at least 12 weeks; 3. No more than 3 lesions; 4. The oncologist judges the patients who can be treated with FMT; 5. Men and women are not limited. Aged 18 to 80 years; 6. Cartensite energy status score >= 70; 7. No grade 3 hypertension, no coronary heart disease, respiratory system and other diseases, good liver function (total bilirubin (T.BIL) <75µMOL/L, direct bilirubin (D.BIL) <39µMOL/L and CHILD-PUGH score A or B); 8. The subjects voluntarily joined the study, signed the informed consent form, had good compliance, and cooperated with the follow-up.

Exclusion criteria

Exclusion criteria: 1. Complicated infections of extraintestinal organs, such as pneumonia, peritonitis, and pleural abscess disease, require antibiotic treatment; 2. Patients with active infection (HAV, HBV, HCV, HIV, syphilis, tuberculosis infection); 3. Severe heart, lung, liver and kidney insufficiency; 4. Severe anemia (Hb<6gdl/g), multiple lymphadenopathy, leukopenia, etc.; 5. Pregnant women or patients with pregnancy plans; 6. Other excluded items will be checked in detail in the outpatient clinic according to the research plan.

Design outcomes

Primary

MeasureTime frame
objective response rate;progression-free survival;overall survival;serum albumin;safety;

Secondary

MeasureTime frame
16S intestinal microflora health assessment;Immune function;

Countries

China

Contacts

Public ContactMohammed Alnaggar

Tongji Chibi Hospital of Huazhong University of Science and Technology (Chibi Pufang Hospital)

dralnaggar@163.com+86 13826185510

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026