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Multimodal MRI study on the relationship between post-stroke social cognitive dysfunction and the disconnection of cortical cholinergic pathways

Multimodal MRI study on the relationship between post-stroke social cognitive dysfunction and the disconnection of cortical cholinergic pathways

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100049407
Enrollment
Unknown
Registered
2021-08-02
Start date
2021-09-01
Completion date
Unknown
Last updated
2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Case series:No

Sponsors

Dongguan People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 80 years; 2. The first ischemic stroke. The diagnostic criteria for ischemic stroke conform to the WHO diagnostic criteria for ischemic stroke; 3. Patients with acute ischemic stroke in the anterior circulation determined by brain MRI-DWI sequence; 4. National Institute of Health stroke scale (NIHSS) <= 15 points on admission; 5. Modified Rankin Scale (mRS) <= 2 points at discharge; 6. Patients or their family members signed the informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Patients with clinical diagnosis of transient ischemic attack; 2. No acute cerebral infarction lesions were found in the brain MRI-DWI sequence; 3. Complicated with hemorrhagic stroke (including cerebral hemorrhage and subarachnoid hemorrhage) or symptomatic hemorrhagic transformation; 4. Patients with severe heart, lung, liver, kidney disease and malignant tumor; 5. Those without cranial MRI data or incomplete data; 6. Past history of dementia, mental disorder and major depressive episode, or current obvious cognitive impairment or major depression.

Design outcomes

Primary

MeasureTime frame
Social cognition;

Countries

China

Contacts

Public ContactQu Jianfeng

Dongguan People's Hospital

geoffrey-197830@163.com+86 13763121818

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026