Parkinson's Disease
Conditions
Interventions
Control group:Sham stimulation
Sponsors
Xinhua Hospital Af?liated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Fulfill the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease; 2.Clear response to levodopa treatment and stable anti-Parkinsonian drug dose for at least one month prior to study participation; 3.Hoehn & Yahr stage was I-III; 4.There was FOG (nFOG-Q >=1 score) and experienced neurologist was required to observe the occurrence of FOG; 5.Can walk at least 10m independently without the help of assistive devices; 6.Ability to cooperate with evaluation and inspection.
Exclusion criteria
Exclusion criteria: 1.Presence of contraindication to rTMS treatment or MRI scan. 2.History of deep brain stimulation (DBS) surgery. 3.History of exposure to rTMS in the past (to minimizing risk of unblinding sham condition); 4.Severe organic diseases (heart disease, tuberculosis, nephritis, etc.), severe lumbar disc herniation or other orthopedic diseases, etc.; 5.Concise Mental State Test (MMSE) <24; 6.Obvious head tremor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in frequency and severity of frozen gait; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gait parameter test changes;Scale assessment of change; | — |
Countries
China
Contacts
Public ContactGan Jing
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed