Postoperative pain of pulmonary nodules
Conditions
Interventions
control group:5mg tropisetron
N1 group:1ug/kg nalmefene
N2group:2ug/kg nalmefene
Sponsors
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 65 years; 2) Selective general anesthesia and VAST partial lung resection; 3) Postoperative sufentanil PCIA analgesia; 4) ASA I - II level; 5) BMI, 18 kg/m2 or and 30 kg/m2 or less; 6) Informed consent of patients.
Exclusion criteria
Exclusion criteria: 1) Preoperative history of chronic pain; 2) Preoperative elevated intracranial pressure, motion sickness, glaucoma, severe hypertension or other diseases causing nausea and vomiting; 3) Pregnancy or lactation; 4) Allergic history of anesthetic drugs and non-steroidal anti-inflammatory drugs; 5) Long-term use of opiates and drug addiction; 6) The patient was diagnosed with severe heart, lung and brain diseases, active heart disease, ischemic heart disease, coronary artery bypass surgery, peripheral artery/cerebrovascular disease, abnormal liver function (AST and ALT greater than 1.5 times the normal value), and abnormal renal function (serum creatinine and urea nitrogen more than 1.2 times the normal value). 7) Participate in other clinical trials or chemoradiotherapy within 4 weeks; 8) Active gastrointestinal ulcer or gastrointestinal bleeding, inflammatory bowel disease; 9) Cognitive or communication abnormalities as determined by the investigator; 10) Plan to be admitted to ICU after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosage of sufentanil in analgesia pump; | — |
Secondary
| Measure | Time frame |
|---|---|
| NumericalPainRating Scale;Postoperative nausea;Postoperative vomiting;Amount of analgesic medication;Antiemetic drug dosage;Ramsay sedation score;Time of first defecation;Pruritus; | — |
Countries
China
Contacts
Public ContactXinchuan Wei
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
Outcome results
None listed