Advanced gastric cancer
Conditions
Interventions
Case series:PF plan, FLOFOX plan or SOX plan
Sponsors
The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Locally advanced gastric cancer (cT2-4aN0-3M0, American Joint Committee on Cancer's AJCC Cancer Staging Manual), and the pathological type of gastroscopy biopsy is gastric adenocarcinoma, including papillary adenocarcinoma, signet ring cell carcinoma and tubular adenocarcinoma; 2.Aged 18 to 75 years; 3.ECOG score of 0-1; 4.Agree to receive neoadjuvant chemotherapy and surgical treatment; 5.Gastroscopy biopsy before neoadjuvant chemotherapy, and tumor specimens obtained; 6.Routine CT examination before neoadjuvant chemotherapy; 7.All Inspections, treatments and evaluations are all carried out in the two centers where the project is expected to be implemented.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of other malignant tumors; 2.Patients contraindicated to anisodamine (such as glaucoma, prostatic hypertrophy), patients allergic to iodine contrast agents, or pyloric obstruction; 3.Patients with poor CT image quality or small lesions that cannot be delineated; 4.Patients with poor pathological image quality due to H&E staining or WSI scanning process errors; 5.Patients with chemotherapy contraindications, or unable to complete neoadjuvant chemotherapy for various reasons; 6.Patients who refuse radical gastric cancer surgery , Or patients undergoing surgery 1 month after the completion of neoadjuvant chemotherapy; 7.Patients whose tissue samples cannot be evaluated by TRG after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Imaging features;Pathological characteristics; | — |
Countries
China
Contacts
Public ContactLi Zhenhui
The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital)
Outcome results
None listed