Knee joint disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. With indications for total knee arthroplasty, including: (1) knee osteoarthritis; (2) rheumatoid arthritis; (3) traumatic arthritis; (4) severe pain and/or dysfunction caused by lesions such as avascular necrosis or tumor; 3. The patient or legal representative has been informed of the nature of the study, understands the provisions in the protocol, and is able to ensure compliance.
Exclusion criteria
Exclusion criteria: 1. Venous thromboembolism has occurred before surgery (except for intramuscular venous thrombosis); 2. Use anticoagulants within 3 days before enrollment; 3. There is a high risk of bleeding, such as active gastrointestinal ulcers, congenital or acquired bleeding abnormalities (platelet count = 2 times during the study period; 5. Renal damage (creatinine clearance <= 20ml/min); 6. Accompanying severe blood disease or immune disease, or (and) receiving hormone therapy; 7. There are contraindications to antiplatelet, anticoagulant and thrombolytic drugs; 8. Active infection or neuroarthritis; 9. Flexor dysfunction, unable to actively bend the knee; 10. Asymptomatic knee stiffness; 11. There are serious medical and surgical underlying diseases before the operation, which makes the patient's walking severely restricted; 12. The patient participates in other clinical studies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Venous thromboembolic events; | — |
Countries
China
Contacts
Fuyang People's Hospital