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Multimodal MRI study on the similarities and differences of response patterns between migraine and tension headache treated with the same acupuncture prescription

Prediction of the efficacy of acupuncture for migraine based on neuroimaging-COMT gene polymorphism

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049296
Enrollment
Unknown
Registered
2021-07-29
Start date
2021-09-01
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine, tension-type headache

Interventions

Sponsors

Chengdu University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria for migraine and tension headache subjects: (1) Aged between 18 and 65 years; (2) Migraine subjects meet the diagnostic criteria: meet the ICHD-3 version of the diagnostic criteria for migraine (without aura) issued by the International Headache Society in 2018; (3) Tension-type headache subjects meet the diagnostic criteria: meet the diagnostic criteria for frequent tension-type headache in the ''International Classification of Headache Disorders'' (ICHD-3) formulated by the International Headache Association in 2018; (4) Right-handed; (5) History of migraine or tension-type headache for more than 6 months; (6) In the past 3 months, migraine or tension-type headache attacked more than once a month; (7) Have not received acupuncture treatment in the past 3 months; (8) In the past 3 months, did not take migraine or tension-type headache preventive drugs, long-acting analgesics, psychotropic drugs (such as Prozac, sulfamethoxazole) and vasoactive drugs; (9) The subject himself or his immediate family signed the informed consent. 2. Inclusion criteria for healthy people: (1) Aged between 18 and 65 years; (2) Right-handed; (3) No medication or acupuncture treatment in the past 3 months; (4) After the examination of relevant clinical indicators in the hospital, the subjects were diagnosed with normal imaging, laboratory and physical signs, and there were no complications such as diabetes, heart disease and other diseases; (5) Have not participated in other clinical projects; (6) Do not have any headache and other pain; (7) The subjects themselves signed or their immediate family members signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Suffering from other types of pain; 2. Suffering from mental disorders and other diseases; 3. Patients with cognitive impairment who cannot cooperate with examination and treatment; 4. Patients with serious primary diseases such as cancer, circulatory system, respiratory system, digestive system, hematopoietic system; 5. Pregnant or lactating patients; 6. Those with a history of alcohol, drug abuse, or drug dependence; 7. There are contraindications to acupuncture; 8. There are contraindications to MRI (such as metal implants in the body, or claustrophobia syndrome, etc.).

Design outcomes

Primary

MeasureTime frame
Multimodal image data;

Secondary

MeasureTime frame
Number of headache days;Number of headache attacks;Effective rate;Emotion-related scale;Emotion-related scale;The use of non-steroidal drug;

Countries

China

Contacts

Public ContactLi Zhengjie

Chengdu University of Traditional Chinese Medicine

lzjbenjamin@163.com+86 18215675610

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026