coronary heart disease
Conditions
Interventions
Experimental group:esketamine
Control group:normal saline
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years, gender is not limited; 2. Patients undergoing open heart surgery under elective general anesthesia; 3. Body mass index (BMI) >= 19 and <= 30 kg/m^2; 4. ASA is classified as II-III; 5. Non-emergency inpatients who have undergone routine preoperative preparation; 6. Voluntarily participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of valve or coronary artery bypass surgery; 2. Patients with coronary artery bypass surgery, aortic surgery, severe aortic atherosclerosis; 3. Patients with myocardial infarction, severe myocardial ischemia, severe hypertension or other serious heart diseases; 4. Those with bronchial asthma, chronic respiratory diseases or other serious respiratory diseases; 5. Patients with craniocerebral injury, intracranial lesions and elevated intracranial pressure; 6. Complicated with neurological disease, mental illness or intellectual disability, unable to correctly describe their own feelings or unable to understand the VAS score, and will not use PCA; 7. Patients with glaucoma or other elevated intraocular pressure; 8. Preoperative ALT, AST >= 1.5 times the upper limit of normal, or Cr > 1.5 times the upper limit of normal; 9. Acute alcoholism or alcohol dependence; 10. Those who are addicted and resistant to opioids; 11. Long-term use of opioid analgesics, general anesthetics, sedatives, hypnotics or other central nervous system depressants; 12. Allergic constitution or known history of allergy to the drugs specified in this research protocol (esketamine, ketamine, morphine, tropisetron, dexamethasone, midazolam, propofol, sufentanil, cisatracurium, remifentanil, atropine, ephedrine, flurbiprofen axetil, etc.); 13. Those who have participated in other clinical trials within 3 months before screening; 14. Pregnant and lactating patients; 15. In addition to the above, the patients who are judged by the researchers to be unsuitable for participation are patients with pulmonary diseases (asthma, emphysema, chronic obstructive pulmonary disease, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baker depression inventory score;IL-6;IL-8;TNF-a;C reactive protein;Troponin T;Creatine kinase-isozyme MB;Blood pressure;Heart rate;Hospitalization time;Detention time in ICU; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;Adverse effect; | — |
Countries
China
Contacts
Public ContactSun Lixin
Qingdao Municipal Hospital
Outcome results
None listed