None listed
Conditions
Interventions
Experimental group:high-flux and hemodiafiltration
Control group:low-flux dialysis and hemodiafiltration
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Chronic kidney disease stage 5; 2. At least 3 months of maintenance hemodialysis treatment in the research center (3 times of dialysis/week), and plan to continue maintenance dialysis treatment during the study period; 3. The patient has a fully functional arteriovenous fistula (AVF) or graft vascular access that can provide a blood flow rate of at least 250 mL/min; 4. Aged 18-80 years, voluntarily participate in the research and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Prepare or have received kidney transplantation; 2. Combined with malignant tumors that affect survival; 3. Severe congestive heart failure, NYHA class IV; unstable angina; acute coronary syndrome and/or myocardial infarction three months before the start of the study; 4. Systemic infection, such as tuberculosis, systemic fungal infection, AIDS, hepatitis; 5. Liver cirrhosis; 6. Pregnant and lactating patients; 7. Other clinicians believe that the overall condition is serious or unsuitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ß2-microglobulin clearance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular and cerebrovascular events and mortality composite outcome indicators;Calcium and phosphorus PTH compliance rate;Inflammatory markers;Pittsburgh sleep quality index, PSQI;Pruritus scale;Pain scale; | — |
Countries
China
Contacts
Public ContactYu Shaobin
West China Hospital, Sichuan University
Outcome results
None listed