Immunocompromise after transplantation
Conditions
Interventions
patient group:None
control group:None
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Group of patients receiving kidney transplantation: (1) Aged >= 18 years, gender is not limited; (2) End-stage renal disease meets the criteria for kidney transplantation, and receives primary allogeneic kidney transplantation; (3) Not receiving any immunomodulatory therapy before receiving transplantation; (4) Accept standard triple immunosuppression regimen after transplantation, namely CNI (cyclosporine/tacrolimus) + MPA (mycophenolate mofetil/mycophenolate sodium enteric-coated tablet) + glucocorticoid; (5) Obtain informed consent and sign an informed consent form. 2. Healthy control group: (1) Aged >= 18 years, gender is not limited; (2) No chronic underlying diseases and no immunosuppressive agents; (3) No infectious disease in the past 1 month; (4) Obtain informed consent and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with co-infection before a clear diagnosis; 2. Patients with tumors, blood system diseases, rheumatic immune system diseases, and HIV diseases; 3. Patients who have received solid organ transplantation other than kidney; 4. Patients with uncontrollable neurological, mental diseases or mental disorders, poor compliance and unable to cooperate; 5. Patients who have joined other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune cell subsets; | — |
Countries
China
Contacts
Public ContactKuang Zhongshu
Zhongshan Hospital Fudan University
Outcome results
None listed