Schizophrenia
Conditions
Interventions
Sponsors
Mental Health Center, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of the International Classification of Diseases (ICD-10) for schizophrenia; 2. In line with the dialectical treatment of epilepsy syndrome of liver-qi stagnation and phlegm-qi stagnation in TCM internal medicine; 3. Take olanzapine before entering the group, the dose will be stable for more than 2 weeks, and the treatment plan will remain unchanged during the study period; 4. Positive and Negative Psychiatric Symptom Scale (PANSS) > 60 points, and Negative Symptom Scale (SANS) total score >= 50 points at the time of enrollment; 5. Gender is not limited, aged 18-65 years; 6. The informed consent form for participating in this study shall be signed by the subjects themselves or their legal guardians.
Exclusion criteria
Exclusion criteria: 1. Serious physical disease, organic brain disease, traumatic brain injury, etc.; 2. Psychotic symptoms secondary to other physical diseases; 3. There is a clear risk of suicide or endangerment to self or others; 4. Patients with Yin deficiency and internal heat type diagnosed by TCM pulse diagnosis; 5. Two or more items >= 4 points (P1, P3, P5, P6, G9); 6. Calgary Schizophrenia Depression Scale total score > 6; 7. The sum of the first 8 items on the Simpson Angus Scale (SAS) is >3; 8. Meets ICD-10 diagnosis of any other psychiatric disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale of negative symptoms(SANS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Event-related potentials;Clinical assessment interview for negative symptoms(CAINS);Positive and negative syndrome scale;Gross clinical impression scale;TCM symptom scale;Side effect scale;Blood 5-hydroxytryptamine;Blood brain-derived neurotrophic factor;Blood gamma-aminobutyric acid;Blood glutamic acid;Blood dopamine; | — |
Countries
China
Contacts
Public ContactZhao Jing
Mental Health Center, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed