Evaluation of the effect of esketamine hydrochloride in cesarean section under combined spinal-epidural anesthesia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100049256

Enrollment

Unknown

Registered

2021-07-28

Start date

2021-08-10

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group N:Isometric saline

Group E1 :Intravenous esketamine 0.25mg/kg

Group E2 :Intravenous esketamine 0.5mg/kg

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Singleton and full-term pregnant women undergoing elective cesarean section of the lower uterine segment under combined spinal-epidural anesthesia. 2. Aged 22-35 years, weight 50-80kg. 3. American Society of Anesthesiologists (ASA) grade I or II.

Exclusion criteria

Exclusion criteria: 1. Contraindications for spinal anesthesia. 2. History of cardiopulmonary disease, history of Parkinson's disease, history of thyroid disease. 3. History of taking psychotropic drugs. 4. Pregnancy complications, fetal distress, stillbirth.

Design outcomes

Primary

Measure	Time frame
blood pressure;degree of blood oxygen saturation;heart rate;breath rate;height;weight;PAED score;FLACC score;visual analogue scale scoring;drug dosage;operation time;anesthesia time;wake up time;liquid volume;adverse reaction;	—

Countries

China

Contacts

Public ContactXue Rui

People Hospital of Shiyan City

xuerui1106@126.com+86 13476167178

Outcome results