An exploratory study on the identification of pathogenic microorganisms based on targeted next-generation sequencing and nanopore sequencing

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100049195

Enrollment

Unknown

Registered

2021-07-25

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infectious Diseases

Interventions

pulmonary infection group:No

spontaneous peritonitis group:No

Eligibility

Sex/Gender

All

Age

18 Years to 79 Years

Inclusion criteria

Inclusion criteria: 1. Pulmonary infection group (1) Meet the diagnostic criteria for community-acquired pneumonia or hospital-acquired pneumonia: 1) Community-acquired pneumonia; 2) Hospital-acquired pneumonia. (2) Aged 18 to 79 years, gender is not limited; (3) Voluntarily signed the informed consent. 2. Spontaneous peritonitis group (1) Patients with decompensated liver cirrhosis who were hospitalized in the Center for Infection and Liver Diseases of the Second Affiliated Hospital of Chongqing Medical University, with a high degree of suspected or confirmed SBP; (2) Combined with a large amount of ascites; (3) Those who underwent paracentesis or ascites ultrafiltration and concentrated reinfusion; (4) Aged 18 to 79 years, gender is not limited; (5) Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1.Pulmonary infection group (1) non-infectious diseases; (2) Only upper respiratory tract infection; (3) Only other parts of the infection; (4) Those who are not willing to participate in this study. 2.Spontaneous peritonitis group (1) Patients with active gastrointestinal bleeding; (2) Systemic circulatory failure that is difficult to correct; (3) At the end of the disease or hospice care period; (4) Patients with hepatic encephalopathy or mental disorder can not cooperate well with treatment; (5) Secondary immunodeficiency patients; (6) Those who are not willing to participate in this study.

Design outcomes

Primary

Measure	Time frame
Detection results of pathogenic microorganisms by culture, tNGS and nanopore sequencing;	—

Countries

China

Contacts

Public ContactHu Peng

The Second Affiliated Hospital of Chongqing Medical University

hp_cq@163.com+86 13608338064

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026