Autoimmune Diseases, Inflammatory Disorder
Conditions
Interventions
AIIRD:COVID-19 vaccine
HC:COVID-19 vaccine
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 67 Years
Inclusion criteria
Inclusion criteria: 1. AIIRD group: 1) Over 18 years old; 2) Patients with informed and voluntary enrollment; 3) Patients with autoimmune diseases or inflammatory diseases (including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, vasculitis, Behcet syndrome, systemic sclerosis, antiphospholipid antibody syndrome, etc.) 4) Treatment with immunomodulator and/ or immunosuppressants. 2. Healthy controls: 1) Over 18 years old; 2) Patients with informed and voluntary enrollment; 3. Patients without autoimmune diseases or inflammatory diseases (including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, vasculitis, Behcet syndrome, systemic sclerosis, antiphospholipid antibody syndrome, etc.) 4. Absence of treatment with immunomodulator and/ or immunosuppressants.
Exclusion criteria
Exclusion criteria: had a history of Covid-SARS-2 infection; Those with positive Covid-SARS-2 antibody or RNA test before vaccination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse reactions after the first, the second and the third dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| SARS-CoV-2 specific antibodies;Covid-SARS-2 neutralizing antibodies;Immunophenotyping of peripheral blood mononuclear cells; | — |
Countries
China
Contacts
Public ContactJing He
Peking University People's Hospital
Outcome results
None listed