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Using Binocular Asynchronous Visual Images to Improve Amblyopic Eyes

A Randomized Controlled Study on lmproving Anisometropic Amblyopia with Binocular Asynchronous Visual lmages Training and Traditional Occlusion Therapy

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049130
Enrollment
Unknown
Registered
2021-07-21
Start date
2014-05-01
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amblyopia

Interventions

Experiment:Visual Training
Control:Patching

Sponsors

Peking University School of Basic Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
4 Years to 8 Years

Inclusion criteria

Inclusion criteria: 1. Children 4-8 years old with no obvious ocular pathology, including optic nerve or macular lesions, media opacities, or abnormalities of the central visual pathways; 2. Significant anisometropia (>1.5 D difference between eyes in spherical equivalent; >1.0 D difference between the eyes in astigmatism, in any meridian.); 3. Optimal refraction prescribed by clinicians with extensive expertise in amblyopia. All had been wearing glasses for more than 3 months and had stable best-corrected visual acuity before entering the study; 4. VA in the AE before treatment between 20/32 Snellen acuity (0.2 logMAR) and 20/200 (1.0 logMAR). This definition for the threshold for amblyopia is slightly more stringent than that of the American Academy of Ophthalmology (VA in the AE before treatment 20/30 Snellen, 0.18 logMAR, or worse) 69. The majority of children had initial VA in the AE worse than 0.3 logMAR; 5. The physical examination of Peking University First Hospital confirmed that the participants had normal psychophysiological development and did not suffer from any acute or chronic diseases or genetic visual system diseases.

Exclusion criteria

Exclusion criteria: 1. Does not meet the screening criteria for the degree of amblyopia; 2. Clinical examination revealed any ocular disease in both eyes; 3. Participants in the experimental group had previously received any visual training to correct amblyopia. Participants in the control group received more than four weeks of occlusion treatment; 4. The physical examination of Peking University First Hospital confirmed that the participants had abnormal psychophysiological development or had any acute or chronic diseases or genetic visual system diseases; 5. Voluntary subjects are excluded from participating in this study when they are found to have any of the above-mentioned examination results; 6. Children assigned to a movie-viewing group received any other form of visual training therapy during the study period.

Design outcomes

Primary

MeasureTime frame
Distance Visual Acuity;

Countries

China

Contacts

Public ContactMingliang Pu

Peking University School of Basic Medical Sciences

mpu@bjmu.edu.cn+86 13501177695

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026