IgA nephropathy
Conditions
Interventions
Intervention group:ACEI/ARB+oral probiotics
Control group:ACEI/ARB+oral placebo
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. IgAN confirmed by a biopsy of kidney puncture pathology; 2. No antibiotics or probiotics were taken within 1 month; 3. Aged>16 years; 4. 0.75g 60mL/min/1.73 m^2.
Exclusion criteria
Exclusion criteria: 1.Other autoimmune diseases or secondary kidney diseases, such as allergic purpura, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, diabetic nephropathy, cirrhosis, nephrotoxic drugs, etc.; 2.After blood analysis, stool examination, fecal occyblood test and colonoscopy or barium examination, organic lesions of colon, rectum and anus; 3.History of malignant tumor; 4.History of neuropsychiatric diseases; 5.Metabolic diseases such as hyperthyroidism, diabetes and gout; 6.Patients who had received or required hormone and/or immunosuppressant therapy prior to enrollment in the study; 7.Patients who cannot be regularly followed up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| albumin-to-creatinine ratio;estimated glomerular filtration rate;double serum creatinine level and/or epidermal growth factor receptor <15 mL/min or initiate renal replacement therapy or die; | — |
Secondary
| Measure | Time frame |
|---|---|
| complete response rate;partial response rate; | — |
Countries
China
Contacts
Public ContactQin Wei
West China Hospital of Sichuan University
Outcome results
None listed