Hematological Disease
Conditions
Interventions
Experimental group:Polymyxin B treatment
Sponsors
The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The patient was diagnosed as hematological malignancy, with a history of CRPA colonization or infection (previous or current stool screening, throat swab, skin swab or secretion, sputum culture or blood culture with CRPA), and continued fever after initial treatment with broad-spectrum antibiotics, (oral temperature >= 38.3 degree C (armpit / ear temperature >= 38.0 degree C) or >= 38.0 degree C (armpit / ear temperature >= 37.7 degree C) for more than 1 h); 2. Aged >= 18 years old; 3. Good liver and kidney function: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) and total bilirubin were less than 2 times of the upper limit of normal; Serum creatinine < 176 u The creatinine clearance rate was more than 50 ml / min / 1.73 m^2; 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Combined with other malignant tumors; 2.Pregnant or lactating women; 3.Patients who participated in other clinical trials at the same time; 4.Conditions that other researchers consider inappropriate for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions to polymyxin B; | — |
Countries
China
Contacts
Public ContactYe Baodong
The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine
Outcome results
None listed