hemorrhagic shock
Conditions
Interventions
Dexmedetomidine group:continuous infusion of dexmedetomidine
Control Group:given equal volume of normal saline
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 69 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with hemorrhagic shock requiring emergency surgery under general anesthesia, ASA III or IV, aged 16 to 70 years, willing to participate in this study and signed a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with abnormal cardiac conduction, hypertension and chronic kidney disease; 2. Those who need emergency surgery due to renal or craniocerebral trauma; 3. Patients with multiple organ failure; 4. Those who are allergic to dexmedetomidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentrations of serum NGAL, creatinine and blood urea nitrogen;intraoperative hemodynamic parameters;concentrations of serum HMGB1,IL-33; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood gas analysis results;indexs of clinical outcome; | — |
Countries
China
Contacts
Public ContactLuo Foquan
The First Affiliated Hospital of Nanchang University
Outcome results
None listed