Acute pancreatitis with hypertriglyceridemia
Conditions
Interventions
Plasma exchange group:plasma exchange
Conventional treatment group:Conventional treatment group
Sponsors
Beijing Luhe Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adults (18-70 years old); 2. Within 48 hours of onset, the diagnosis of HTG-AP is clear; 3. TG>1000mg/dL (11.3mmol/L) at the time of enrollment, and accompanied by any one or more of the following clinical manifestations: (1) Lactic acid>2mmol/L and pH38.5? or 90 beats/min; 3) Breathing>20 times/min or PaCO2>32mmHg; 4) WBC count>12000/ml or 10%; (4) Organ failure was assessed by modified Marshall score.
Exclusion criteria
Exclusion criteria: 1. AP caused by other causes other than hyperlipidemia, such as gallstones, alcohol, etc 2. Patients with uncorrected acidosis (pH =6.5mmol/L) requiring emergency CRRT at the time of randomization; 3. Contraindication to plasma exchange: severe allergic history to plasma, human serum albumin, heparin, etc.;There are mental disorders and can not cooperate well with treatment;Systemic circulatory failure that is difficult to correct with drugs;Unstable heart and cerebral infarction;Intracranial hemorrhage or severe cerebral edema accompanied by cerebral hernia; 4. Patients refuse plasmapheresis without informed consent, and other conditions that may bring significant bias; 5. Pregnant and lactating women;Or subjects (including male subjects) who plan to become pregnant within 1 month after the trial; 6. Sponsors or researchers directly involved in the trial or their family members; 7. The investigator determined that there was any reason for the ineligibility, such as the expectation that the patient would die within 48 hours of enrolment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| triglyceride;hemodiastase; | — |
Countries
China
Contacts
Public ContactWeng Yibing
Beijing Luhe Hospital
Outcome results
None listed