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Analysis of the influencing factors of rebound pain after single shot peripheral nerve block

Effects of different routes of dexamethasone administration on postoperative rebound pain in patients with single nerve block

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049075
Enrollment
Unknown
Registered
2021-07-20
Start date
2021-08-01
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain

Interventions

The control group:The popliteal sciatic nerve block and adductor canal block were performed with 0.375% ropivacaine 28ml.
test group 1:The drug was 0.375% ropivacaine 28ml+10mg dexamethasone for popliteal sciatic nerve block and adductor canal block.
test group 2:The drug was 0.375% ropivacaine 28ml for popliteal sciatic nerve block and adductor canal block, and intravenous dexamethasone 10mg

Sponsors

The Third Affiliated Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-80 years; 2. ASA I - III level; 3. Subjects who underwent orthopedic surgery for elective open reduction and internal fixation of ankle fractures; 4. Voluntarily participated and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Preoperative combined peripheral nerve injury or disease; 2. Long-term oral painkillers for chronic pain; 3. Serious compound trauma; 4. Pregnant women; 5. A history of steroid use within two weeks of the study; 6. There are contraindications for regional block; 7. Patients with contraindications to dexamethasone (mental health disorders, cataracts, glaucoma, bacteremia and systemic fungal infections, peptic ulcer disease, viral infections such as herpes or recent live vaccines); 8. The patient has a history of allergy to the study drug, a diabetic patient; 9. The wound is infected.

Design outcomes

Primary

MeasureTime frame
rebound pain;sleep quality during the night of surgery day and POD1;Blood inflammation related indicators;

Secondary

MeasureTime frame
Duration of sensory and motor nerve block;Patient satisfaction;Patient satisfaction score;Patient satisfaction score;

Countries

China

Contacts

Public ContactWang Qiujun

The Third Affiliated Hospital of Hebei Medical University

13933178001@163.com+86 18533112929

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026