intraoperative sedation
Conditions
Interventions
midazolam-alfentanil combination group:alfentanil and midazolam intravenous bolus
midazolam-fentanyl combination group:fentanyl and midazolam intravenous bolus
Sponsors
Beilun People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Clinical patients who agree to participate in the research program; 2. Have clear indications for fiberoptic bronchoscopy; 3. Aged 18 to 60 years old.
Exclusion criteria
Exclusion criteria: 1. Perennial alcohol addiction, long-term use of drugs that affect mental state (such as sedatives) and monoamine oxidase inhibitors; 2. Combined with severe liver dysfunction (Child-Pugh class C); renal dysfunction (dialysis before surgery); 3. Combined mental and psychological disorders lead to impaired cognitive function; 4. Patients with bronchial asthma, respiratory depression, myasthenia gravis and high sensitivity; 5. Pregnant women; 6. Aged over 60 years old, or less than 18 years old; 7. Arrhythmia, preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats/min) or second degree and above atrioventricular block, pacing is installed device.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate;biood pressure;oxygen saturation of blood;Ramsay sedation score;VAS score of cough response; | — |
Countries
China
Contacts
Public ContactCao Yunfei
Beilun People's Hospital
Outcome results
None listed